Photoacoustic imaging of cerebral blood vessels in a rat for monitoring drug delivery to the brain tissue

Ryota Watanabe, Shunichi Sato, Yasuyuki Tsunoi, Satoko Kawauchi, Hiroshi Ashida, Mitsuhiro Terakawa

    研究成果: Article査読

    抄録

    In general, it is difficult to deliver a drug to the brain transvascularly due to the blood-brain barrier. To develop a method for drug delivery to the brain, a modality that enables imaging both of the cerebral blood vessels and a drug is needed. In this study, we developed a compact photoacoustic imaging system, by which label-free imaging of the cerebral blood vessels in a rat was performed in vivo. By compensating the attenuation of excitation light in brain tissue, blood vessels with diameters larger than 50 μm were visualized in the depth range up to ~2 mm.

    本文言語English
    ページ(範囲)O-110-O-111
    ジャーナルTransactions of Japanese Society for Medical and Biological Engineering
    52
    DOI
    出版ステータスPublished - 2014 8 17

    ASJC Scopus subject areas

    • Biomedical Engineering

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