Photosensitization reaction-induced electrical blockade in myocardial tissue

A. Ito, S. Hosokawa, S. Miyoshi, K. Soejima, T. Arai

研究成果: Conference contribution

2 被引用数 (Scopus)

抄録

We proposed the application of photodynamic therapy (PDT) as a new type of atrial fibrillation treatment. PDT is well known as a practical cancer treatment using cytotoxicity of reactive oxygen species generated by the photochemical interaction. We predicted that the photocytotoxic effect induced by PDT might cause electrical blockade in myocardial tissue. We studied the electrical blockade induced by the PDT with talaporfin sodium in vitro, ex vivo, and in vivo. The cell lethality measurement using rat cardiac myocytes confirmed the PDT-induced photocytotoxic effect and its dependence on the loading time of the photosensitizer. In ex vivo experiment using rat right ventricle, the PDT caused a shutdown of the stimulated electrical signal propagation. The long-lasting atrioventricular block induced by the PDT was obtained in vivo experiment with rat heart. These results revealed the possibility of atrial fibrillation treatment with the PDT.

本文言語English
ホスト出版物のタイトルProceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08
ページ4361-4363
ページ数3
出版ステータスPublished - 2008 12 1
イベント30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - Vancouver, BC, Canada
継続期間: 2008 8 202008 8 25

出版物シリーズ

名前Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - "Personalized Healthcare through Technology"

Other

Other30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08
国/地域Canada
CityVancouver, BC
Period08/8/2008/8/25

ASJC Scopus subject areas

  • コンピュータ ビジョンおよびパターン認識
  • 信号処理
  • 生体医工学
  • 健康情報学

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