Physicochemical properties of amphoteric β‐lactam antibiotics II: Solubility and dissolution behavior of aminocephalosporins as a function of pH

Akira Tsuji, Emi Nakashima, Tsukinaka Yamana

研究成果: Article査読

30 被引用数 (Scopus)

抄録

The solubility of aminocephalosporins in aqueous solution at 37° and an ionic strength of 0.5 exhibited U‐shaped curves against pH. At their isoelectric pH, cephradine monohydrate was the most soluble, followed by cephalexin monohydrate and cephaloglycin dihydrate, with intrinsic solubilities of 26.0, 17.2, and 14.8 mg/ml, respectively. The dissolution rate constants from the rotating disk were also determined as a function of the pH of the dissolution medium and interpreted reasonably by the simultaneous dissociation equilibrium reaction and the diffusion kinetics model. Energies for the solubility and dissolution were determined for these three aminocephalosporins.

本文言語English
ページ(範囲)308-311
ページ数4
ジャーナルJournal of Pharmaceutical Sciences
68
3
DOI
出版ステータスPublished - 1979 3

ASJC Scopus subject areas

  • Pharmaceutical Science

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