TY - JOUR
T1 - Physicochemical properties of amphoteric β‐lactam antibiotics II
T2 - Solubility and dissolution behavior of aminocephalosporins as a function of pH
AU - Tsuji, Akira
AU - Nakashima, Emi
AU - Yamana, Tsukinaka
PY - 1979/3
Y1 - 1979/3
N2 - The solubility of aminocephalosporins in aqueous solution at 37° and an ionic strength of 0.5 exhibited U‐shaped curves against pH. At their isoelectric pH, cephradine monohydrate was the most soluble, followed by cephalexin monohydrate and cephaloglycin dihydrate, with intrinsic solubilities of 26.0, 17.2, and 14.8 mg/ml, respectively. The dissolution rate constants from the rotating disk were also determined as a function of the pH of the dissolution medium and interpreted reasonably by the simultaneous dissociation equilibrium reaction and the diffusion kinetics model. Energies for the solubility and dissolution were determined for these three aminocephalosporins.
AB - The solubility of aminocephalosporins in aqueous solution at 37° and an ionic strength of 0.5 exhibited U‐shaped curves against pH. At their isoelectric pH, cephradine monohydrate was the most soluble, followed by cephalexin monohydrate and cephaloglycin dihydrate, with intrinsic solubilities of 26.0, 17.2, and 14.8 mg/ml, respectively. The dissolution rate constants from the rotating disk were also determined as a function of the pH of the dissolution medium and interpreted reasonably by the simultaneous dissociation equilibrium reaction and the diffusion kinetics model. Energies for the solubility and dissolution were determined for these three aminocephalosporins.
KW - Aminocephalosporins, various—solubility and dissolution, effect of pH
KW - Antibacterials—various aminocephalosporins, solubility and dissolution, effect of pH
KW - Dissolution—various aminocephalosporins, effect of pH
KW - Solubility—various aminocephalosporins, effect of pH
KW - β‐Lactam antibiotics—various aminocephalosporins, solubility and dissolution, effect of pH
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U2 - 10.1002/jps.2600680313
DO - 10.1002/jps.2600680313
M3 - Article
C2 - 34022
AN - SCOPUS:0018350802
VL - 68
SP - 308
EP - 311
JO - Journal of Pharmaceutical Sciences
JF - Journal of Pharmaceutical Sciences
SN - 0022-3549
IS - 3
ER -