Physicochemical properties of pDNA/chitosan complexes as gene delivery systems

Kenji Hagiwara, Riany Anastasia, Mitsuhiro Nakata, Toshinori Sato

研究成果: Article査読

3 被引用数 (Scopus)

抄録

Successful gene therapy depends on the development of effective gene carriers. Naturally occurring chitosan has been employed widely as a non-viral gene carrier because of its low toxicity, low immunogenicity, biocompatibility, and biodegradability. In this review, we summarize the utilization of chitosan, modified chitosan, and chitosan-containing ternary complexes as gene carriers. In particular, we discuss the influence of the physicochemical features of pDNA/chitosan complexes on their functions, such as stability and gene transfer into cells.

本文言語English
ページ(範囲)329-339
ページ数11
ジャーナルCurrent Drug Discovery Technologies
8
4
DOI
出版ステータスPublished - 2011 12 1

ASJC Scopus subject areas

  • 創薬

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