Physiologically based pharmacokinetic model for cefazolin in rabbits and its preliminary extrapolation to man

Medicine & Life Sciences

• Anti-Bacterial Agents 6%
• Blood Proteins 9%
• Bone and Bones 12%
• Cefazolin 82%
• Extracellular Fluid 12%
• Inulin 13%
• Kidney 11%
• Lactams 15%
• Liver 5%
• Lung 5%
• Myocardium 8%
• Pharmaceutical Preparations 4%
• Pharmacokinetics 48%
• Protein Binding 10%
• Proteins 3%
• Rabbits 45%
• Renal Insufficiency 9%
• Serum 4%
• Serum Albumin 10%
• Skin 5%

Chemical Compounds

• Antimicrobial Agent 7%
• Cefazolin 100%
• Clearance 11%
• Drug 5%
• Flow 6%
• Interstitial 11%
• Inulin 14%
• Length 6%
• Mass Balance 12%
• Pharmacokinetics 48%
• Plasma 26%
• Protein 8%
• Time 3%
• Volume 6%