@article{53ee0b701493483e9c471fd4fb128bd7,
title = "Pilot Study Evaluating Regulatory T Cell-Promoting Immunosuppression and Nonimmunogenic Donor Antigen Delivery in a Nonhuman Primate Islet Allotransplantation Model",
abstract = "The full potential of islet transplantation will only be realized through the development of tolerogenic regimens that obviate the need for maintenance immunosuppression. Here, we report an immunotherapy regimen that combines 1-ethyl-3-(3′-dimethylaminopropyl)-carbodiimide (ECDI)-treated donor lymphoid cell infusion (ECDI-DLI) with thymoglobulin, anti-interleukin-6 receptor antibody and rapamycin to achieve prolonged allogeneic islet graft survival in a nonhuman primate (NHP) model. Prolonged graft survival is associated with Treg expansion, donor-specific T cell hyporesponsiveness and a transient absence of donor-specific alloantibody production during the period of graft survival. This regimen shows promise for clinical translation.",
keywords = "Donor-specific hyporesponsiveness, donor-specific transfusion/antigen delivery, graft survival, tolerance, tolerance: depletion",
author = "J. Lei and Kim, {J. I.} and S. Shi and X. Zhang and Z. Machaidze and S. Lee and C. Schuetz and Martins, {P. N.} and T. Oura and Farkash, {E. A.} and Rosales, {I. A.} and Smith, {R. N.} and R. Stott and Lee, {K. M.} and J. Soohoo and S. Boskovic and K. Cappetta and Nadazdin, {O. M.} and Y. Yamada and H. Yeh and T. Kawai and Sachs, {D. H.} and G. Benichou and Markmann, {J. F.}",
note = "Publisher Copyright: {\textcopyright} Copyright 2015 The American Society of Transplantation and the American Society of Transplant Surgeons.",
year = "2015",
month = oct,
day = "1",
doi = "10.1111/ajt.13329",
language = "English",
volume = "15",
pages = "2739--2749",
journal = "American Journal of Transplantation",
issn = "1600-6135",
publisher = "Wiley-Blackwell",
number = "10",
}