Pilot Study Evaluating Regulatory T Cell-Promoting Immunosuppression and Nonimmunogenic Donor Antigen Delivery in a Nonhuman Primate Islet Allotransplantation Model

J. Lei, J. I. Kim, S. Shi, X. Zhang, Z. Machaidze, S. Lee, C. Schuetz, P. N. Martins, T. Oura, E. A. Farkash, I. A. Rosales, R. N. Smith, R. Stott, K. M. Lee, J. Soohoo, S. Boskovic, K. Cappetta, O. M. Nadazdin, Y. Yamada, H. YehT. Kawai, D. H. Sachs, G. Benichou, J. F. Markmann

研究成果: Article査読

25 被引用数 (Scopus)

抄録

The full potential of islet transplantation will only be realized through the development of tolerogenic regimens that obviate the need for maintenance immunosuppression. Here, we report an immunotherapy regimen that combines 1-ethyl-3-(3′-dimethylaminopropyl)-carbodiimide (ECDI)-treated donor lymphoid cell infusion (ECDI-DLI) with thymoglobulin, anti-interleukin-6 receptor antibody and rapamycin to achieve prolonged allogeneic islet graft survival in a nonhuman primate (NHP) model. Prolonged graft survival is associated with Treg expansion, donor-specific T cell hyporesponsiveness and a transient absence of donor-specific alloantibody production during the period of graft survival. This regimen shows promise for clinical translation.

本文言語English
ページ(範囲)2739-2749
ページ数11
ジャーナルAmerican Journal of Transplantation
15
10
DOI
出版ステータスPublished - 2015 10月 1
外部発表はい

ASJC Scopus subject areas

  • 免疫アレルギー学
  • 移植
  • 薬理学(医学)

フィンガープリント

「Pilot Study Evaluating Regulatory T Cell-Promoting Immunosuppression and Nonimmunogenic Donor Antigen Delivery in a Nonhuman Primate Islet Allotransplantation Model」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル