Pinnarine, another member of the halichlorine family. Isolation and preparation from pinnaic acid

Shu Xu, Hideaki Yoshimura, Norihito Maru, Osamu Ohno, Hirokazu Arimoto, Daisuke Uemura

研究成果: Article査読

9 被引用数 (Scopus)

抄録

Pinnarine (1), a new macrocyclic alkaloid, was isolated from the black marine sponge Halichondria okadai. The structure was elucidated on the basis of 2D NMR and comparison with the spectra of the co-isolated known halichlorine. Further confirmation of the structure and the absolute configuration was validated by a synthetic method from authentic pinnaic acid and CD analysis. The isolation of pinnarine also suggested a biogenetic pathway from pinnaic acid to halichlorine. (Chemical Equation Presented).

本文言語English
ページ(範囲)1323-1326
ページ数4
ジャーナルJournal of Natural Products
74
5
DOI
出版ステータスPublished - 2011 5 27

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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