抄録
The regulated incorporation of AMPA receptors into synapses is important for synaptic plasticity. Here we examine the role of protein kinase A (PKA) in this process. We found that PKA phosphorylation of the AMPA receptor subunits GluR4 and GluR1 directly controlled the synaptic incorporation of AMPA receptors in organotypic slices from rat hippocampus. Activity-driven PKA phosphorylation of GluR4 was necessary and sufficient to relieve a retention interaction and drive receptors into synapses. In contrast, PKA phosphorylation of GluR1 and the activity of calcium/calmodulin-dependent kinase II (CaMKII) were both necessary for receptor incorporation. Thus, PKA phosphorylation of AMPA receptor subunits contributes to diverse mechanisms underlying synaptic plasticity.
本文言語 | English |
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ページ(範囲) | 136-143 |
ページ数 | 8 |
ジャーナル | Nature Neuroscience |
巻 | 6 |
号 | 2 |
DOI | |
出版ステータス | Published - 2003 2月 1 |
外部発表 | はい |
ASJC Scopus subject areas
- 神経科学(全般)