TY - CHAP
T1 - Plant-based mucosal vaccine delivery systems
AU - Azegami, Tatsuhiko
AU - Yuki, Yoshikazu
AU - Kiyono, Hiroshi
N1 - Publisher Copyright:
© 2020 Elsevier Inc. All rights reserved.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Plant-based vaccines (PbVs), developed with novel plant genetic engineering technologies, offer a new strategy for the production, storage, and delivery of vaccines. PbVs can overcome practical and economic concerns surrounding injectable vaccines, including the need for medical staff to perform the injections and the costs of production and refrigeration. The development of unrefrigerated, needle-free vaccines will support the prevention of infectious diseases in developing countries. Although no PbV has yet been licensed for human clinical use, some are now in clinical trials. Antigen-encoding genes introduced into potatoes, lettuce, spinach, corn, tobacco, soybeans, and rice can produce vaccines against mucosal and systemic infectious diseases, including enterotoxigenic Escherichia coli, Vibrio cholerae, norovirus, influenza virus, hepatitis B virus, and rabies virus. This chapter introduces the plant genetic engineering technologies used and clinical trials of PbVs.
AB - Plant-based vaccines (PbVs), developed with novel plant genetic engineering technologies, offer a new strategy for the production, storage, and delivery of vaccines. PbVs can overcome practical and economic concerns surrounding injectable vaccines, including the need for medical staff to perform the injections and the costs of production and refrigeration. The development of unrefrigerated, needle-free vaccines will support the prevention of infectious diseases in developing countries. Although no PbV has yet been licensed for human clinical use, some are now in clinical trials. Antigen-encoding genes introduced into potatoes, lettuce, spinach, corn, tobacco, soybeans, and rice can produce vaccines against mucosal and systemic infectious diseases, including enterotoxigenic Escherichia coli, Vibrio cholerae, norovirus, influenza virus, hepatitis B virus, and rabies virus. This chapter introduces the plant genetic engineering technologies used and clinical trials of PbVs.
KW - Agrobacterium
KW - Capsid protein
KW - Cholera toxin
KW - HBs antigen
KW - Heat-labile enterotoxin
KW - Hemagglutinin
KW - MucoRice
KW - Oral vaccine
KW - Plant-based vaccine
KW - SIgA
UR - http://www.scopus.com/inward/record.url?scp=85080805627&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85080805627&partnerID=8YFLogxK
U2 - 10.1016/B978-0-12-811924-2.00020-1
DO - 10.1016/B978-0-12-811924-2.00020-1
M3 - Chapter
AN - SCOPUS:85080805627
SN - 9780128119259
SP - 357
EP - 370
BT - Mucosal Vaccines
PB - Elsevier
ER -