Plasma cytokine profiles related to smoking-sensitivity and phenotypes of chronic obstructive pulmonary disease

Miho Nakamura, Hidetoshi Nakamura, Naoto Minematsu, Shotaro Chubachi, Masaki Miyazaki, Shuichi Yoshida, Keishi Tsuduki, Toru Shirahata, Shuko Mashimo, Saeko Takahashi, Takahiro Nakajima, Hiroki Tateno, Seitaro Fujishima, Tomoko Betsuyaku

研究成果: Article

7 引用 (Scopus)

抄録

Chronic obstructive pulmonary disease (COPD) develops only in smoking-sensitive smokers and manifests heterogeneous phenotypes, including emphysema and non-emphysema types. We aimed to identify biomarkers related to the smoking-sensitivity and phenotypes of COPD. Among 240 smokers suggestive of COPD, we studied on four groups defined by % forced expiratory volume in one second (FEV1) and computed tomography-based pulmonary emphysema. Plasma concentrations of 33 inflammatory markers were measured in four groups as well as Non-smokers using multiplex protein arrays. IL-5, IL-7 and IL-13 were identified to be associated with smoking sensitivity and IL-6 and IL-10 were candidate biomarkers for airway-lesion dominant COPD.

元の言語English
ページ(範囲)368-377
ページ数10
ジャーナルBiomarkers
19
発行部数5
DOI
出版物ステータスPublished - 2014

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Pulmonary diseases
Chronic Obstructive Pulmonary Disease
Smoking
Cytokines
Phenotype
Plasmas
Biomarkers
Interleukin-7
Protein Array Analysis
Pulmonary Emphysema
Interleukin-13
Interleukin-5
Emphysema
Forced Expiratory Volume
Interleukin-10
Tomography
Interleukin-6
Proteins

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Health, Toxicology and Mutagenesis
  • Medicine(all)

これを引用

Plasma cytokine profiles related to smoking-sensitivity and phenotypes of chronic obstructive pulmonary disease. / Nakamura, Miho; Nakamura, Hidetoshi; Minematsu, Naoto; Chubachi, Shotaro; Miyazaki, Masaki; Yoshida, Shuichi; Tsuduki, Keishi; Shirahata, Toru; Mashimo, Shuko; Takahashi, Saeko; Nakajima, Takahiro; Tateno, Hiroki; Fujishima, Seitaro; Betsuyaku, Tomoko.

:: Biomarkers, 巻 19, 番号 5, 2014, p. 368-377.

研究成果: Article

Nakamura, M, Nakamura, H, Minematsu, N, Chubachi, S, Miyazaki, M, Yoshida, S, Tsuduki, K, Shirahata, T, Mashimo, S, Takahashi, S, Nakajima, T, Tateno, H, Fujishima, S & Betsuyaku, T 2014, 'Plasma cytokine profiles related to smoking-sensitivity and phenotypes of chronic obstructive pulmonary disease', Biomarkers, 巻. 19, 番号 5, pp. 368-377. https://doi.org/10.3109/1354750X.2014.915342
Nakamura, Miho ; Nakamura, Hidetoshi ; Minematsu, Naoto ; Chubachi, Shotaro ; Miyazaki, Masaki ; Yoshida, Shuichi ; Tsuduki, Keishi ; Shirahata, Toru ; Mashimo, Shuko ; Takahashi, Saeko ; Nakajima, Takahiro ; Tateno, Hiroki ; Fujishima, Seitaro ; Betsuyaku, Tomoko. / Plasma cytokine profiles related to smoking-sensitivity and phenotypes of chronic obstructive pulmonary disease. :: Biomarkers. 2014 ; 巻 19, 番号 5. pp. 368-377.
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AU - Nakamura, Hidetoshi

AU - Minematsu, Naoto

AU - Chubachi, Shotaro

AU - Miyazaki, Masaki

AU - Yoshida, Shuichi

AU - Tsuduki, Keishi

AU - Shirahata, Toru

AU - Mashimo, Shuko

AU - Takahashi, Saeko

AU - Nakajima, Takahiro

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AU - Betsuyaku, Tomoko

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AB - Chronic obstructive pulmonary disease (COPD) develops only in smoking-sensitive smokers and manifests heterogeneous phenotypes, including emphysema and non-emphysema types. We aimed to identify biomarkers related to the smoking-sensitivity and phenotypes of COPD. Among 240 smokers suggestive of COPD, we studied on four groups defined by % forced expiratory volume in one second (FEV1) and computed tomography-based pulmonary emphysema. Plasma concentrations of 33 inflammatory markers were measured in four groups as well as Non-smokers using multiplex protein arrays. IL-5, IL-7 and IL-13 were identified to be associated with smoking sensitivity and IL-6 and IL-10 were candidate biomarkers for airway-lesion dominant COPD.

KW - Airflow limitation

KW - Chronic obstructive pulmonary disease

KW - Emphysema

KW - Inflammatory cytokine

KW - Plasma biomarker

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