Plasma levels of brain and atrial natriuretic peptides elevate in proportion to left ventricular end-systolic wall stress in patients with aortic stenosis.

T. Ikeda, K. Matsuda, H. Itoh, G. Shirakami, Y. Miyamoto, T. Yoshimasa, K. Nakao, T. Ban

研究成果: Article

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Brain natriuretic peptide (BNP) is a novel cardiac hormone secreted predominantly from the ventricle. We examined the plasma levels of BNP and atrial natriuretic peptide (ANP) in 13 patients with aortic stenosis undergoing corrective surgery. Preoperative plasma BNP and ANP levels correlated highly with preoperative left ventricular end-systolic wall stress (ESS) (r = 0.96, p < 0.0001 and r = 0.95, p < 0.0001, respectively). Moreover, between preoperative and late postoperative states, the difference of the plasma levels of BNP and ANP correlated with the difference of ESS. In two patients with elevated ESS and quite high preoperative plasma BNP (> 1000 pg/ml), rapid decrease of the plasma level after operation was observed. These results suggest that synthesis and secretion of BNP and ANP are stimulated by the increase of left ventricular end-systolic wall stress in patients with aortic stenosis.

元の言語English
ページ(範囲)307-314
ページ数8
ジャーナルAmerican heart journal
133
発行部数3
DOI
出版物ステータスPublished - 1997 3
外部発表Yes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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