Platelet activating factor-induced early pregnancy factor activity from the perfused rabbit ovary and oviduct

Kou Sueoka, A. M. Dharmarajan, Toyohiko Miyazaki, Susan J. Atlas, Edward E. Wallach

研究成果: Article査読

16 被引用数 (Scopus)

抄録

Early pregnancy factor, a glycoprotein, and platelet activating factor, a phospholipid, are early signals of pregnancy appearing during the preimplantation period. The aim of this study was to determine if the administration of platelet activating factor to rabbits would stimulate the production of early pregnancy factor and, if so, to ascertain the organs responsible. Early pregnancy factor was assayed after the administration of synthetic platelet activating factor to intact rabbits, rabbits that had undergone bilateral salpingo-oophorectomy, and isolated in vitro perfused rabbit ovary and/or oviduct. Although serum early pregnancy factor activity was detectable 30 minutes after platelet activating factor injection in intact rabbits, no activity was found in rabbits whose ovaries and oviducts had been removed. Perfusate early pregnancy factor activity was detectable only in the presence of both ovary and oviduct, and was first evident 120 minutes after platelet activating factor exposure. However, combined samples of perfusates from the ovary alone and oviduct alone expressed positive early pregnancy factor activity. Furthemore, the addition of platelet activating factor to either single or combined perfusates did not increase early pregnancy factor activity. Our data imply that platelet activating factor induces the production of ovary and oviduct early pregnancy factor components independently. (AM J Obstet GYNECOL 1988;159:1580-4.).

本文言語English
ページ(範囲)1580-1584
ページ数5
ジャーナルAmerican Journal of Obstetrics and Gynecology
159
6
DOI
出版ステータスPublished - 1988 12

ASJC Scopus subject areas

  • 産婦人科学

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