Pleiotropic effects of nifedipine on atherosclerosis

Sho Ichi Yamagishi, Kazuo Nakamura, Katsuhiko Takenaka, Takanori Matsui, Hiroyoshi Inoue

研究成果: Review article査読

25 被引用数 (Scopus)

抄録

Impaired endothelial cell (EC) growth and function have been proposed to be an initial event that leads to the development of atherosclerosis. There is a growing body of evidence that atherosclerosis is an inflammatory-fibroproliferative disease, and ECs are target for cytokines and growth factors released during inflammation. Recently, nifedipine, one of the most widely used dihydropyridine-based calcium antagonists (DHPs) for treatments of patients with hypertension, was shown to inhibit vascular inflammation and subsequently improve endothelial function in many cardiovascular diseases, thus slowing the development and progression of atherosclerosis. However, the molecular mechanisms underlying this are not fully understood, because ECs do not possess voltage-operated L-type calcium channels. In this review, we discuss the pleiotropic effects of nifedipine on atherosclerosis, especially focusing on its anti-oxidative properties.

本文言語English
ページ(範囲)1543-1547
ページ数5
ジャーナルCurrent Pharmaceutical Design
12
12
DOI
出版ステータスPublished - 2006 4 1
外部発表はい

ASJC Scopus subject areas

  • 薬理学
  • 創薬

フィンガープリント

「Pleiotropic effects of nifedipine on atherosclerosis」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル