Polarization of Reactive Astrocytes in Response to Spinal Cord Injury is Enhanced by M2 Macrophage–Mediated Activation of Wnt/β-Catenin Pathway

Iki Sonn, Masaya Nakamura, Francois Renault-Mihara, Hideyuki Okano

研究成果: Article査読

10 被引用数 (Scopus)

抄録

Understanding the mechanisms of glial scar formation by reactive astrocytes is crucial for elaborating a therapeutic strategy to brain and spinal cord injury. However, the extrinsic mechanisms that drive the polarization of reactive astrocytes, the first step in glial scar formation, remain poorly understood. Here, using an in vitro chemotaxis assay as an experimental model for polarization, we observed that Il4-M2 macrophages are stronger inducers of reactive astrocytes’ polarization, compared to naive or M1 macrophages. Then, we showed that both β1-integrin and Wnt/β-catenin pathways in astrocytes are required for this polarization in vitro and in vivo after spinal cord crush injury in mice. These findings provide molecular targets for manipulating the polarization of reactive astrocytes in order to potentially enhance the healing of SCI lesions.

本文言語English
ページ(範囲)1847-1862
ページ数16
ジャーナルMolecular Neurobiology
57
4
DOI
出版ステータスPublished - 2020 4月 1

ASJC Scopus subject areas

  • 神経学
  • 細胞および分子神経科学

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