Poly(2-methacryloyloxyethyl phosphorylcholine) (MPC) nanofibers coated with micro-patterned diamond-like carbon (DLC) for the controlled drug release

Kenta Bito, Tomoki Maeda, Katsuya Hagiwara, Soki Yoshida, Terumitsu Hasebe, Atsushi Hotta

研究成果: Article査読

4 被引用数 (Scopus)

抄録

Attaining high hemocompatibility and promoting endothelialization are two major keys to solve the endoleak problems observed in existing stent-grafts. For the satisfactory long-term use of the stent-grafts, blocking the endoleak symptom is highly essential. This paper deals with the fabrication of electrospun nanofibers made of antithrombogenic poly(2-methacryloyloxyethyl phosphorylcholine) (MPC) containing drug that can sustain the endothelial activity of the MPC nanofibers. Moreover, the drug release was controlled by micro-patterned diamond-like carbon (DLC) coated on the MPC nanofibers. It was found that MPC nanofibers retained excellent hemocompatibility and that the micro-patterned DLC efficiently controlled the drug-release rate of MPC fibers.

本文言語English
ページ(範囲)51-55
ページ数5
ジャーナルJournal of Biorheology
29
1
DOI
出版ステータスPublished - 2015

ASJC Scopus subject areas

  • 材料科学(全般)
  • 材料力学
  • 機械工学

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