Polymorphisms in genes encoding antioxidant enzymes (SOD2, CAT, GPx, TXNRD, SEPP1, SEP15 and SELS) and risk of chronic kidney disease in Japanese - Cross-sectional data from the J-MICC study

Asahi Hishida, Rieko Okada, Mariko Naito, Emi Morita, Kenji Wakai, Nobuyuki Hamajima, Satoyo Hosono, Hinako Nanri, Tanvir Chowdhury Turin, Sadao Suzuki, Kazuyo Kuwabara, Haruo Mikami, Sanjeev Budhathoki, Isao Watanabe, Kokichi Arisawa, Michiaki Kubo, Hideo Tanaka

研究成果: Article査読

8 被引用数 (Scopus)

抄録

Chronic kidney disease (CKD) is well known as a strong risk factor for both of end-stage renal disease and cardiovascular disease. To clarify the association of polymorphisms in the genes encoding antioxidant enzymes (SOD2, CAT, GPx, TXNRD. SEPP1, SEP15 and SELS) with the risk of CKD in Japanese, we examined this association using the cross-sectional data of Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. The subjects were 3,285 men and women, aged 35-69 years, selected from J-MICC Study participants for whom genotyping were conducted by multiplex polymerase chain reaction-based Invader assay. The prevalence of CKD was determined for CKD stages 3-5 (eGFR <60 ml/min/1.73 m2). When those with CATC-262T C/C were defined as reference, those with CAT C-262T C/T demonstrated the OR for CKD of 0.67 (95% CI 0.43-1.06) with the marginally significant trend for decreased odds ratio with increasing numbers of T allele (p = 0.070). There were no significant associations between the other polymorphisms with CKD risk. The present study found a marginally significant trend of the decreased risk of CKD with increasing numbers of T allele of CAT, which may suggest the possibility of personalized risk estimation of this life-limiting disease in the near future.

本文言語English
ページ(範囲)15-20
ページ数6
ジャーナルJournal of Clinical Biochemistry and Nutrition
53
1
DOI
出版ステータスPublished - 2013 8 1
外部発表はい

ASJC Scopus subject areas

  • 医学(その他)
  • 栄養および糖尿病
  • 臨床生化学

フィンガープリント

「Polymorphisms in genes encoding antioxidant enzymes (SOD2, CAT, GPx, TXNRD, SEPP1, SEP15 and SELS) and risk of chronic kidney disease in Japanese - Cross-sectional data from the J-MICC study」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル