Polymorphisms of dopamine receptor and transporter genes and Parkinson's disease

S. Higuchi, T. Muramatsu, H. Arai, M. Hayashida, H. Sasaki, J. Q. Trojanowski

研究成果: Article査読

42 被引用数 (Scopus)

抄録

Disturbances of the dopamine system are involved in the pathogenesis of idiopathic Parkinson's disease (PD). Although genetic factors may play a role in the etiology of PD, there is little direct evidence implicating a specific gene. We conducted a study to test the hypothesis that allelic variations of the dopamine receptors (D2, D3, D4) and the dopamine transporter (DAT) contribute to the susceptibility to PD. Association analyses of 70 Japanese PD patients and the same number of age-matched controls did not reveal any association between alleles of the D2, D3 or D4 receptor genes or the DAT gene and PD. Thus, our results suggest that factor(s) other than allelic variations of these key proteins in the dopamine system contribute to the susceptibility to PD.

本文言語English
ページ(範囲)107-113
ページ数7
ジャーナルJournal of Neural Transmission - Parkinson's Disease and Dementia Section
10
2-3
DOI
出版ステータスPublished - 1995 6
外部発表はい

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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