TY - JOUR
T1 - Poly(N-isopropylacrylamide) based thermoresponsive polymer brushes for bioseparation, cellular tissue fabrication, and nano actuators
AU - Nagase, Kenichi
AU - Okano, Teruo
AU - Kanazawa, Hideko
N1 - Funding Information:
This work was supported by SENTAN from the Japan Science and Technology Agency (JST) , the A3 Foresight Program “Nano-Biomaterials and Delivery Strategies in Regenerative Medicine for Intractable Diseases” from the Japan Society for the Promotion of Science (JSPS) , and by a Grant-in-aid for Scientific Research (No. 26420714 and No. 16H05083 ) from the JSPS , Creation of Innovation Centers For Advanced Interdisciplinary Research Areas Program in the Project for Developing Innovation Systems “Cell Sheet Tissue Engineering Center (CSTEC)” from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) , Japan.
Publisher Copyright:
© 2018 Elsevier B.V.
PY - 2018/10
Y1 - 2018/10
N2 - Many thermoresponsive surfaces for biomedical applications have been developed using various techniques for modifying substrates with thermoresponsive polymers. In addition, surface-initiated living radical polymerization methods such as atom-transfer radical polymerization (ATRP) and reversible addition–fragmentation chain-transfer (RAFT) polymerization have been developed as nano structure controlled surface modification methods for modifying thermoresponsive polymers to substrates. These polymerization techniques allow the accurate control of polymerization and the formation of densely packed polymer brush structures. The present review article summarizes a variety of thermoresponsive polymer brushes, mainly comprising poly(N-isopropylacrylamide) (PIPAAm), prepared by surface-initiated ATRP and RAFT polymerization. Self-oscillating polymer brushes as new nano-actuators are also discussed.
AB - Many thermoresponsive surfaces for biomedical applications have been developed using various techniques for modifying substrates with thermoresponsive polymers. In addition, surface-initiated living radical polymerization methods such as atom-transfer radical polymerization (ATRP) and reversible addition–fragmentation chain-transfer (RAFT) polymerization have been developed as nano structure controlled surface modification methods for modifying thermoresponsive polymers to substrates. These polymerization techniques allow the accurate control of polymerization and the formation of densely packed polymer brush structures. The present review article summarizes a variety of thermoresponsive polymer brushes, mainly comprising poly(N-isopropylacrylamide) (PIPAAm), prepared by surface-initiated ATRP and RAFT polymerization. Self-oscillating polymer brushes as new nano-actuators are also discussed.
KW - Bioseparation
KW - Regenerative medicine
KW - Surface modification
KW - Thermoresponsive surface
KW - Tissue engineering
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U2 - 10.1016/j.nanoso.2018.03.010
DO - 10.1016/j.nanoso.2018.03.010
M3 - Review article
AN - SCOPUS:85045014868
VL - 16
SP - 9
EP - 23
JO - Nano-Structures and Nano-Objects
JF - Nano-Structures and Nano-Objects
SN - 2352-507X
ER -