抄録
Polyoxypeptin, a potent inducer of apoptosis in human pancreatic carcinoma cells, was isolated from an ethyl acetate extract of a Streptomyces culture broth. Structural determination by 2D-NMR and X-ray crystallographic analysis revealed that it is a novel cyclic hexadepsipeptide containing five hydroxylated amino acids. The unusual and hitherto unreported amino acid 3-hydroxy-3-methylproline was one of them.
本文言語 | English |
---|---|
ページ(範囲) | 1389-1392 |
ページ数 | 4 |
ジャーナル | Tetrahedron Letters |
巻 | 39 |
号 | 11 |
DOI | |
出版ステータス | Published - 1998 3月 12 |
ASJC Scopus subject areas
- 生化学
- 創薬
- 有機化学