Polyoxypeptin isolated from Streptomyces: A bioactive cyclic depsipeptide containing the novel amino acid 3-hydroxy-3-methylproline

Kazuo Umezawa; Kumi Nakazawa; Toshio Uemura; Yoko Ikeda; Shinichi Kondo; Hiroshi Naganawa; Naoko Kinoshita; Hideki Hashizume; Masa Hamada; Tomio Takeuchi; Shigeru Ohba

doi:10.1016/S0040-4039(98)00031-8

Polyoxypeptin isolated from Streptomyces: A bioactive cyclic depsipeptide containing the novel amino acid 3-hydroxy-3-methylproline

Kazuo Umezawa, Kumi Nakazawa, Toshio Uemura, Yoko Ikeda, Shinichi Kondo, Hiroshi Naganawa, Naoko Kinoshita, Hideki Hashizume, Masa Hamada, Tomio Takeuchi, Shigeru Ohba

人文社会学科

研究成果: Article › 査読

55 被引用数 (Scopus)

抄録

Polyoxypeptin, a potent inducer of apoptosis in human pancreatic carcinoma cells, was isolated from an ethyl acetate extract of a Streptomyces culture broth. Structural determination by 2D-NMR and X-ray crystallographic analysis revealed that it is a novel cyclic hexadepsipeptide containing five hydroxylated amino acids. The unusual and hitherto unreported amino acid 3-hydroxy-3-methylproline was one of them.

本文言語	English
ページ（範囲）	1389-1392
ページ数	4
ジャーナル	Tetrahedron Letters
巻	39
号	11
DOI	https://doi.org/10.1016/S0040-4039(98)00031-8
出版ステータス	Published - 1998 3 12

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

文献へのアクセス

10.1016/S0040-4039(98)00031-8

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引用スタイル

Polyoxypeptin isolated from Streptomyces : A bioactive cyclic depsipeptide containing the novel amino acid 3-hydroxy-3-methylproline. / Umezawa, Kazuo; Nakazawa, Kumi; Uemura, Toshio; Ikeda, Yoko; Kondo, Shinichi; Naganawa, Hiroshi; Kinoshita, Naoko; Hashizume, Hideki; Hamada, Masa; Takeuchi, Tomio; Ohba, Shigeru.

In: Tetrahedron Letters, Vol. 39, No. 11, 12.03.1998, p. 1389-1392.

研究成果: Article › 査読

Umezawa, Kazuo ; Nakazawa, Kumi ; Uemura, Toshio ; Ikeda, Yoko ; Kondo, Shinichi ; Naganawa, Hiroshi ; Kinoshita, Naoko ; Hashizume, Hideki ; Hamada, Masa ; Takeuchi, Tomio ; Ohba, Shigeru. / Polyoxypeptin isolated from Streptomyces : A bioactive cyclic depsipeptide containing the novel amino acid 3-hydroxy-3-methylproline. In: Tetrahedron Letters. 1998 ; Vol. 39, No. 11. pp. 1389-1392.

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