Polyoxypeptin isolated from Streptomyces: A bioactive cyclic depsipeptide containing the novel amino acid 3-hydroxy-3-methylproline

Kazuo Umezawa; Kumi Nakazawa; Toshio Uemura; Yoko Ikeda; Shinichi Kondo; Hiroshi Naganawa; Naoko Kinoshita; Hideki Hashizume; Masa Hamada; Tomio Takeuchi; Shigeru Ohba

doi:10.1016/S0040-4039(98)00031-8

Polyoxypeptin isolated from Streptomyces: A bioactive cyclic depsipeptide containing the novel amino acid 3-hydroxy-3-methylproline

Kazuo Umezawa, Kumi Nakazawa, Toshio Uemura, Yoko Ikeda, Shinichi Kondo, Hiroshi Naganawa, Naoko Kinoshita, Hideki Hashizume, Masa Hamada, Tomio Takeuchi, Shigeru Ohba

人文社会学科

研究成果: Article › 査読

57 被引用数 (Scopus)

抄録

Polyoxypeptin, a potent inducer of apoptosis in human pancreatic carcinoma cells, was isolated from an ethyl acetate extract of a Streptomyces culture broth. Structural determination by 2D-NMR and X-ray crystallographic analysis revealed that it is a novel cyclic hexadepsipeptide containing five hydroxylated amino acids. The unusual and hitherto unreported amino acid 3-hydroxy-3-methylproline was one of them.

本文言語	English
ページ（範囲）	1389-1392
ページ数	4
ジャーナル	Tetrahedron Letters
巻	39
号	11
DOI	https://doi.org/10.1016/S0040-4039(98)00031-8
出版ステータス	Published - 1998 3月 12

ASJC Scopus subject areas

生化学
創薬
有機化学

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10.1016/S0040-4039(98)00031-8

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引用スタイル

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author = "Kazuo Umezawa and Kumi Nakazawa and Toshio Uemura and Yoko Ikeda and Shinichi Kondo and Hiroshi Naganawa and Naoko Kinoshita and Hideki Hashizume and Masa Hamada and Tomio Takeuchi and Shigeru Ohba",

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T2 - A bioactive cyclic depsipeptide containing the novel amino acid 3-hydroxy-3-methylproline

AU - Umezawa, Kazuo

AU - Nakazawa, Kumi

AU - Uemura, Toshio

AU - Ikeda, Yoko

AU - Kondo, Shinichi

AU - Naganawa, Hiroshi

AU - Kinoshita, Naoko

AU - Hashizume, Hideki

AU - Hamada, Masa

AU - Takeuchi, Tomio

AU - Ohba, Shigeru

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AB - Polyoxypeptin, a potent inducer of apoptosis in human pancreatic carcinoma cells, was isolated from an ethyl acetate extract of a Streptomyces culture broth. Structural determination by 2D-NMR and X-ray crystallographic analysis revealed that it is a novel cyclic hexadepsipeptide containing five hydroxylated amino acids. The unusual and hitherto unreported amino acid 3-hydroxy-3-methylproline was one of them.

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