Polysaccharide-Coated Liposome with Antimicrobial Agents Against Intracytoplasmic Pathogen and Fungus

Shigeru Kohno, Takashige Miyazaki, Keizo Yamaguchi, Hikaru Tanaka, Toshiaki Hayashi, Masaki Hirota, Atsushi Saito, Kohei Hara, Toshinori Sato, Junzo Sunamoto

研究成果: Article査読

16 被引用数 (Scopus)

抄録

Liposomes which are stabilized by being coated with polysaccharides such as amylopectin and mannan are concentrated in the lung and liver more than simple liposomes without any polysaccharide-coat. These polysaccharidecoated liposomes are easily internalized by macrophages. Amylopectin-coated liposome with ceftazidime (survival rate, 30%) was better than free ceftazidime alone (survival rate, 0%) for the treatment of Legionella pneumonia in guinea pigs. The antibiotic efficacy rate of polysaccharide-coated liposome bearing minocycline (MINO) or ampicillin (ABPC) was much better than that of free MINO or ABPC for the treatment of Listeria infection. These data suggest that polysaccharide-coated liposomes bearing antibiotics are excellent for intracytoplasmic pathogen especially in the reticuloendothelial system where a large population of phagocytes exist.

本文言語English
ページ(範囲)137-147
ページ数11
ジャーナルJournal of Bioactive and Compatible Polymers
3
2
DOI
出版ステータスPublished - 1988 4
外部発表はい

ASJC Scopus subject areas

  • バイオエンジニアリング
  • 生体材料
  • ポリマーおよびプラスチック
  • 材料化学

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