Liposomes which are stabilized by being coated with polysaccharides such as amylopectin and mannan are concentrated in the lung and liver more than simple liposomes without any polysaccharide-coat. These polysaccharidecoated liposomes are easily internalized by macrophages. Amylopectin-coated liposome with ceftazidime (survival rate, 30%) was better than free ceftazidime alone (survival rate, 0%) for the treatment of Legionella pneumonia in guinea pigs. The antibiotic efficacy rate of polysaccharide-coated liposome bearing minocycline (MINO) or ampicillin (ABPC) was much better than that of free MINO or ABPC for the treatment of Listeria infection. These data suggest that polysaccharide-coated liposomes bearing antibiotics are excellent for intracytoplasmic pathogen especially in the reticuloendothelial system where a large population of phagocytes exist.
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