Polyunsaturated Fatty Acid-Derived Lipid Mediators That Regulate Epithelial Homeostasis

Tatsuro Naganuma, Nodoka Fujinami, Makoto Arita

研究成果: Review article査読

抄録

Epithelial tissues are mainly composed of epithelial cells, covering both internal and external surfaces of our body. To maintain epithelial homeostasis, cellular functions, such as proliferation, migration, and differentiation, are flexibly regulated in response to changes in the cellular status, thereby contributing to barrier formation, immune reaction, and wound closure. Polyunsaturated fatty acids (PUFAs) are precursors of various lipid mediators that maintain tissue homeostasis by exerting characteristic bioactivities. This review aimed to summarize the role of PUFA-derived lipid mediators in epithelial cell functions, mainly focusing on the epidermis, cornea, and intestinal epithelium.

本文言語English
ページ(範囲)998-1007
ページ数10
ジャーナルBiological and Pharmaceutical Bulletin
45
8
DOI
出版ステータスPublished - 2022 8月

ASJC Scopus subject areas

  • 薬理学
  • 薬科学

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