Porous polyurethane tubes as vascular graft.

K. Fujimoto, M. Minato, S. Miyamoto, T. Kaneko, H. Kikuchi, K. Sakai, M. Okada, Y. Ikada

研究成果: Article

26 引用 (Scopus)

抜粋

A vascular graft with the inner diameter of about 3 mm was prepared from segmented poly (ether urethane) with an extrusion technique. To make the wall of the vascular grafts porous, NaCl salts were added to the polyurethane solution to be extruded and removed with water extraction after evaporating the solvent in the extruded tube. The wall was reinforced with elastic fiber to prevent dilation. The compliance of the vascular graft measured with the method of Hayashi et al. ranged from 0.2 to 0.3% mmHg -1. The initial Young's modulus was close to that of canine carotic artery, to which the porous polyurethane graft 4-cm long was anastomosed. Vascular grafts were occluded within 2 weeks after implantation, when their pore size was 0, 1.7, or 4.4 mum, whereas those with the pore size of 5.5, 7.4, and 30 mum were patent for longer than 4 weeks. When the vascular graft with the pore size of 30 mum was implanted for 6 months, the luminal surface was covered with neointima, but the endothelium-like cells appearing in the middle of the intima of the vascular graft were immature and sometimes had a very big nucleus. In addition, spindle-shaped, modified smooth muscle cells were noticed in the deep layer of the neointima, especially in the tissue where anastomotic intimal hyperplasia occurred.

元の言語English
ページ(範囲)347-354
ページ数8
ジャーナルJournal of applied biomaterials : an official journal of the Society for Biomaterials
4
発行部数4
DOI
出版物ステータスPublished - 1993 1 1
外部発表Yes

ASJC Scopus subject areas

  • Engineering(all)

フィンガープリント Porous polyurethane tubes as vascular graft.' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用