Porous surface structure fabricated by breath figures that suppresses pseudomonas aeruginosa biofilm formation

Kengo Manabe, Shingo Nishizawa, Seimei Shiratori

研究成果: Article査読

63 被引用数 (Scopus)

抄録

As colonizers of medical-device surfaces, Pseudomonas aeruginosa strains present a serious source of infection and are of major concern. In this study, we fabricated films with porous surfaces by breath figures that disturb mergence by bacterial attachment, thereby impeding biofilm development. Previous studies have shown that microtopography prevents the development of P. aeruginosa biofilms. Accordingly we indented surfaces with patterns of micrometer-sized pores using breath figures at ordinary temperatures and pressures. The antimicrobial effect of surface figures was experimentally investigated by controlling the surface structure. The results suggested that pores of 5-11 μm in diameter effectively inhibit bacterial activity. It appears that biofilm development is precluded by the decreased contact area between the films and bacteria.

本文言語English
ページ(範囲)11900-11905
ページ数6
ジャーナルACS Applied Materials and Interfaces
5
22
DOI
出版ステータスPublished - 2013 11 27

ASJC Scopus subject areas

  • 材料科学(全般)

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