Possible Association between Obesity and Posttransplantation Complications Including Infectious Diseases and Acute Graft-versus-Host Disease

Shigeo Fuji, Sung Won Kim, Ken ichi Yoshimura, Hideki Akiyama, Shin ichiro Okamoto, Hiroshi Sao, Junko Takita, Naoki Kobayashi, Shin ichiro Mori

研究成果: Article

33 引用 (Scopus)

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Both obesity and malnutrition are considered risk factors for complications after bone marrow transplantation (BMT). To elucidate the impact of pretransplantation body mass index (BMI) on clinical outcome, we performed a retrospective cohort study with registration data from the Japan Marrow Donor Program (JMDP). Between January 1998 and December 2005, a total of 3935 patients received unrelated BMT through the JMDP; of these, 3827 patients for whom pretransplantation height and weight data were available were included in the study. Patients were stratified according to pretransplantation BMI values (low BMI: BMI < 18 kg/m2, n = 295; normal BMI: 18 ≤ BMI < 25 kg/m2, n = 2906; overweight: 25 ≤ BMI <30 kg/m2, n = 565; obese: 30 kg/m2 ≤ BMI, n = 61). In a univariate analysis, pretransplantation BMI was associated with a significantly greater risk of grade II-IV acute graft-versus-host disease (GVHD; P = .03). Multivariate analysis showed that pretransplantation BMI tended to be associated with an increased risk of grade II-IV acute GVHD (P = .07). Obesity was associated with an increased risk of infection compared with normal BMI (odds ratio = 1.9; 95% confidence interval = 1.1 to 3.2; P = .02). Our findings demonstrate a correlation between pretransplantation BMI and posttransplantation complications. Although BMI depends strongly on multiple factors, the effect of obesity on clinical outcome should be evaluated in a prospective study.

元の言語English
ページ(範囲)73-82
ページ数10
ジャーナルBiology of Blood and Marrow Transplantation
15
発行部数1
DOI
出版物ステータスPublished - 2009 1 1

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ASJC Scopus subject areas

  • Hematology
  • Transplantation

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