Possible case of potentiation of the antiplatelet effect of cilostazol by grapefruit juice

K. Taniguchi, H. Ohtani, T. Ikemoto, A. Miki, S. Hori, Y. Sawada

研究成果: Article査読

11 被引用数 (Scopus)

抄録

We present a case of purpura associated with concomitant ingestion of cilostazol, aspirin and grapefruit juice. A 79-year-old man with atherosclerosis obliterans, taking cilostazol and aspirin, complained of purpura. Interview by a pharmacist revealed that he had been taking grapefruit juice for a month. His purpura disappeared upon cessation of grapefruit juice, although his medication was not altered. The most probable cause of his purpura is an increase in the blood level of cilostazol because of the inhibition of cilostazol metabolism by components of grapefruit juice. Aspirin may possibly have potentiated the risk of purpura. Grapefruit juice should be avoided in patients taking cilostazol, especially in patients being concomitantly treated with other anticoagulants.

本文言語English
ページ(範囲)457-459
ページ数3
ジャーナルJournal of Clinical Pharmacy and Therapeutics
32
5
DOI
出版ステータスPublished - 2007 10 1
外部発表はい

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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