Possible delayed cut-end recurrence after limited resection for ground-glass opacity adenocarcinoma, Intraoperatively diagnosed as noguchi type B, in three patients

Junji Yoshida, Genichiro Ishii, Tomoyuki Yokose, Keiju Aokage, Tomoyuki Hishida, Mitsuyo Nishimura, Takuya Onuki, Masayuki Noguchi, Kanji Nagai

研究成果: Article査読

51 被引用数 (Scopus)

抄録

INTRODUCTION:: In our limited resection trial of pulmonary peripheral ground-glass opacity (GGO) lesions from 1998 to 2002, limited resection of Noguchi type A and B carcinomas seemed to have a positive outcome. However, recently three of the 24 patients, with mixed GGO lesions intraoperatively diagnosed as type B, developed a solid lesion at the cut-end scar. METHODS:: Medical records and radiology and pathology findings of the three patients were reviewed. We also analyzed epidermal growth factor receptor gene mutations when possible. RESULTS:: Radiologically, these three second tumors were clearly cut-end scar area recurrences. However, other pathologic and mutation findings suggest metachronous primary cancers developed in Case 1, cut-end recurrence in Case 2, and needle biopsy implantation in Case 3. It is difficult to definitively conclude whether the second tumors were recurrences or metachronous primaries. CONCLUSIONS:: These second tumors have convinced us that our initial caution in concluding GGO lesions can be cured by limited resection was very appropriate. The recurrences definitely indicate that continuing follow-up attention for more than 5 years is needed after limited resection even for GGO bronchioloalveolar carcinomas.

本文言語English
ページ(範囲)546-550
ページ数5
ジャーナルJournal of Thoracic Oncology
5
4
DOI
出版ステータスPublished - 2010 4月
外部発表はい

ASJC Scopus subject areas

  • 腫瘍学
  • 呼吸器内科

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