Posttranscriptional Regulation of MicroRNA Biogenesis in Animals

Haruhiko Siomi, Mikiko C. Siomi

研究成果: Review article査読

462 被引用数 (Scopus)

抄録

MicroRNAs (miRNAs) control gene expression in animals, plants, and unicellular eukaryotes by promoting degradation or repressing translation of target mRNAs. miRNA expression is often tissue specific and developmentally regulated, and regulation occurs both transcriptionally and posttranscriptionally. This regulation is crucial, as alteration of miRNA expression has been linked to human diseases, including several cancers. Here, we discuss recent studies that shed light on how multiple steps in the miRNA biogenesis pathway are regulated to modulate miRNA function in animals.

本文言語English
ページ(範囲)323-332
ページ数10
ジャーナルMolecular Cell
38
3
DOI
出版ステータスPublished - 2010 5月 14

ASJC Scopus subject areas

  • 分子生物学
  • 細胞生物学

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