Posttranslational regulation of cell-surface colony-stimulating factor-1

Keisuke Horiuchi, Yoshiaki Toyama

研究成果: Review article査読

5 被引用数 (Scopus)

抄録

Colony-stimulating factor-1 (CSF-1) plays a central role in the survival, proliferation, differentiation, and function of monocytes and macrophages. CSF-1 is synthesized as both a soluble and a membrane-spanning growth factor. The membrane-spanning isoform is biologically active, but it can also be proteolytically cleaved to generate a soluble growth factor. A recent study revealed that the TNF-α-converting enzyme is involved in this activity, and, moreover, that membrane-spanning CSF-1 undergoes internalization. These findings may have important implications for the posttranslational regulation and the functions of cell-surface CSF-1.

本文言語English
ページ(範囲)215-227
ページ数13
ジャーナルCritical Reviews in Immunology
28
3
DOI
出版ステータスPublished - 2008

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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