抄録
Recent clinical studies have established an important role of angiotensin converting enzyme inhibitors (ACE-I) as a tool for renal protection. Although angiotensin receptor antagonists (AII-A) share the common property with ACE-I with regard to blockade of angiotensin activity via angiotensin type 1 receptors (AT1), AII-A is also reported to stimulate AT2 that plausibly activates nitric oxide production within renal medulla and augments synthesis of vasodilatory P450-metabolites in renal afferent arterioles. In contrast, AII-A is reported to have no effect on bradykinin activity. Results obtained in experimental animals indicate that AII-A effectively prevents the progression of renal injury. Several clinical studies are in progress, and the preliminary results suggest that AII-A has potent renal protective action in a variety of renal disorders.
本文言語 | English |
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ページ(範囲) | 1164-1167 |
ページ数 | 4 |
ジャーナル | Nippon rinsho. Japanese journal of clinical medicine |
巻 | 57 |
号 | 5 |
出版ステータス | Published - 1999 5月 |
ASJC Scopus subject areas
- 医学(全般)