Potential Suppressive Effects of Two C60 Fullerene Derivatives on Acquired Immunity

Toshiro Hirai, Yasuo Yoshioka, Asako Udaka, Eiichiro Uemura, Tomoyuki Ohe, Hisae Aoshima, Jian Qing Gao, Ken Kokubo, Takumi Oshima, Kazuya Nagano, Kazuma Higashisaka, Tadahiko Mashino, Yasuo Tsutsumi

研究成果: Article

4 引用 (Scopus)

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The therapeutic effects of fullerene derivatives on many models of inflammatory disease have been demonstrated. The anti-inflammatory mechanisms of these nanoparticles remain to be elucidated, though their beneficial roles in allergy and autoimmune diseases suggest their suppressive potential in acquired immunity. Here, we evaluated the effects of C60 pyrrolidine tris-acid (C60-P) and polyhydroxylated fullerene (C60(OH)36) on the acquired immune response in vitro and in vivo. In vitro, both C60 derivatives had dose-dependent suppressive effects on T cell receptor-mediated activation of T cells and antibody production by B cells under anti-CD40/IL-4 stimulation, similar to the actions of the antioxidant N-acetylcysteine. In addition, C60-P suppressed ovalbumin-specific antibody production and ovalbumin-specific T cell responses in vivo, although T cell-independent antibodies responses were not affected by C60-P. Together, our data suggest that fullerene derivatives can suppress acquired immune responses that require T cells.

元の言語English
記事番号449
ジャーナルNanoscale Research Letters
11
発行部数1
DOI
出版物ステータスPublished - 2016 12 1

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics

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    Hirai, T., Yoshioka, Y., Udaka, A., Uemura, E., Ohe, T., Aoshima, H., Gao, J. Q., Kokubo, K., Oshima, T., Nagano, K., Higashisaka, K., Mashino, T., & Tsutsumi, Y. (2016). Potential Suppressive Effects of Two C60 Fullerene Derivatives on Acquired Immunity. Nanoscale Research Letters, 11(1), [449]. https://doi.org/10.1186/s11671-016-1663-7