Potential use of biological proteins for liver failure therapy

Kazuaki Taguchi, Keishi Yamasaki, Hakaru Seo, Masaki Otagiri

研究成果: Review article査読

9 被引用数 (Scopus)

抄録

Biological proteins have unlimited potential for use as pharmaceutical products due to their various biological activities, which include non-toxicity, biocompatibility, and biodegradability. Recent scientific advances allow for the development of novel innovative protein-based products that draw on the quality of their innate biological activities. Some of them hold promising potential for novel therapeutic agents/devices for addressing hepatic diseases such as hepatitis, fibrosis, and hepatocarcinomas. This review attempts to provide an overview of the development of protein-based products that take advantage of their biological activity for medication, and discusses possibilities for the therapeutic potential of protein-based products produced through different approaches to specifically target the liver (or hepatic cells: hepatocytes, hepatic stellate cells, liver sinusoidal endothelial cells, and Kupffer cells) in the treatment of hepatic diseases.

本文言語English
ページ(範囲)255-274
ページ数20
ジャーナルPharmaceutics
7
3
DOI
出版ステータスPublished - 2015 8 31
外部発表はい

ASJC Scopus subject areas

  • Pharmaceutical Science

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