PPARs and hypertension

研究成果: Review article査読

1 被引用数 (Scopus)

抄録

PPARs (peroxisome proliferator-activated receptors) alpha, delta and gamma are expressed in adipocytes, skeletal myocytes and hepatocytes and also in endothelial cells, vascular smooth muscle cells and monocytes/macrophages, in distinct distributions. They are critically involved in the pathophysiology of obesity, diabetes, hyperlipidemia and hypertension, the complex of which is recognized as "metabolic syndrome", as well as, of their vascular complications. In addition to modulation of insulin sensitivity, PPARs can regulate oxidative stress and local production of various vasoactive substances in blood vessels, and thus control vascular tone and remodeling as one of the determinants of hypertension.

本文言語English
ページ(範囲)631-642
ページ数12
ジャーナルNippon rinsho. Japanese journal of clinical medicine
63
4
出版ステータスPublished - 2005 4
外部発表はい

ASJC Scopus subject areas

  • 医学(全般)

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