Practical and efficient enantioselective borohydride reduction of aromatic ketones catalyzed by optically active cobalt(II) complexes using pre-modified borohydride

Kiyoaki D. Sugi, Takushi Nagata, Tohru Yamada, Teruaki Mukaiyama

研究成果: Article

44 引用 (Scopus)

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A catalytic enantioselective borohydride reduction of aromatic ketones in presence of 0.1-1 mol% of optically active aldiminato cobalt(II) complex catalysts at 0 °C was successfully achieved using precisely pre-modified borohydride with one equivalent each of tetrahydrofurfuryl alcohol, ethanol and NaBH4. The corresponding secondary alcohols were produced in less than 45 min with high enantiomeric excesses (up to 98% ee). The above method was successfully applied to kinetic and dynamic kinetic resolutions of aromatic ketones.

元の言語English
ページ(範囲)1081-1082
ページ数2
ジャーナルChemistry Letters
発行部数12
DOI
出版物ステータスPublished - 1996 1 1

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ASJC Scopus subject areas

  • Chemistry(all)

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