Predicting the kinetic properties associated with redox imbalance after oxidative crisis in G6PD-deficient erythrocytes: A simulation study

Hanae Shimo, Taiko Nishino, Masaru Tomita

研究成果: Article査読

5 被引用数 (Scopus)

抄録

It is well known that G6PD-deficient individuals are highly susceptible to oxidative stress. However, the differences in the degree of metabolic alterations among patients during an oxidative crisis have not been extensively studied. In this study, we applied mathematical modeling to assess the metabolic changes in erythrocytes of various G6PD-deficient patients during hydrogen peroxide- (H2O2-) induced perturbation and predict the kinetic properties that elicit redox imbalance after exposure to an oxidative agent. Simulation results showed a discrepancy in the ability to restore regular metabolite levels and redox homeostasis among patients. Two trends were observed in the response of redox status (GSH/GSSG) to oxidative stress, a mild decrease associated with slow recovery and a drastic decline associated with rapid recovery. The former was concluded to apply to patients with severe clinical symptoms. Low Vmax and high KmG6P of G6PD were shown to be kinetic properties that enhance consequent redox imbalance.

本文言語English
論文番号398945
ジャーナルAdvances in Hematology
2011
DOI
出版ステータスPublished - 2011

ASJC Scopus subject areas

  • 血液学

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