Prediction of changes in the clinical pharmacokinetics of basic drugs on the basis of octanol-water partition coefficients

Chemical Compounds

• Octanol-Water Partition Coefficient 85%
• Pharmacokinetics 50%
• Plasma Concentration 39%
• Drug 35%
• Clomipramine 35%
• Pentazocine 18%
• Nitrazepam 17%
• Diazepam 14%
• Plasma 13%
• Clearance 12%
• Partition Coefficient 11%
• Fat 11%
• Flow Kinetics 8%
• Volume 6%

Medicine & Life Sciences

• Octanols 100%
• Pharmacokinetics 50%
• Water 44%
• Pharmaceutical Preparations 27%
• Clomipramine 22%
• Intravenous Administration 15%
• Nitrazepam 13%
• Pentazocine 12%
• Rabbits 12%
• Diazepam 9%
• Liver 8%
• Brain 8%
• Fats 6%
• Serum 3%