Prediction of potentially unstable electrical activity during embryonic development of rodent ventricular myocytes

Chikako Okubo, Hitomi Sano, Yasuhiro Naito, Masaru Tomita

研究成果: Conference contribution

抄録

In order to evaluate developmental changes in embryonic ventricular cells at early embryonic (EE) and late embryonic (LE) stage, we aimed to predict potentially unstable action potentials (APs) that could be lethal to developing ventricular cells. Two models of the Kyoto and the Luo-Rudy model were used for simulation of 512 representative combinations by switching the relative activities of 9 ionic components whose activities vary between the EE and LE stages. Out of these 512 combinations in Kyoto model, 144 combinations were predicted potentially unstable resulting from combinations of funny current (If), inward rectifier current (IK1), sustained inward current (Ist), L-type Ca2+ current (ICaL), and Na+ current (INa). Other 208 and 160 combinations were predicted quiescent membrane potentials and regular spontaneous APs. Based on these results, we suggest that sequential switches of the relative activities of INa, If, and IK1 enable cells to avoid unstable patterns.

本文言語English
ホスト出版物のタイトルComputing in Cardiology 2012, CinC 2012
ページ301-304
ページ数4
出版ステータスPublished - 2012
イベント39th Computing in Cardiology Conference, CinC 2012 - Krakow, Poland
継続期間: 2012 9 92012 9 12

出版物シリーズ

名前Computing in Cardiology
39
ISSN(印刷版)2325-8861
ISSN(電子版)2325-887X

Other

Other39th Computing in Cardiology Conference, CinC 2012
国/地域Poland
CityKrakow
Period12/9/912/9/12

ASJC Scopus subject areas

  • コンピュータ サイエンス(全般)
  • 循環器および心血管医学

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