Prediction of the Distribution Volumes of Cefazolin and Tobramycin in Obese Children Based on Physiological Pharmacokinetic Concepts

Rie Koshida, Emi Nakashima, Noboru Taniguchi, Akira Tsuji, Leslie Z. Benet, Fujio Ichimura

研究成果: Article査読

29 被引用数 (Scopus)

抄録

So as to estimate the appropriate dose of antibacterial drugs in obese children, prediction of the volume of distribution in these children was attempted based on physiological pharmacokinetic concepts which had been constructed from results in normal-weight children. Serum concentration–time data after intravenous drip infusions of tobramycin and cefazolin were analyzed using noncompartmental analysis of obese children in whom the degree of obesity ranged from 30 to 80%. Volume of distribution at steady state (Vss) per total body weight of tobramycin was significantly less than that for normal-weight children (P < 0.05), whereas the value of cefazolin was almost equal to that for normal-weight children. The equation to express the difference of Vss between cefazolin and tobramycin obtained in normal-weight children failed in obese children, suggesting that there is a large decrease in the extracellular space in obese children exceeding the interindividual variations in normal-weight children. The Vss value (liter) for tobramycin was predicted by using the equation 0.261 · {ideal body weight (kg) + 0.4 · [total body weight (kg) – ideal body weight (kg)]}. The Vss value of cefazolin was predicted to be 0.3 · (predicted Vss of tobramycin) + 0.052 · total body weight (kg). A good correlation between the predicted and the observed Vss values was obtained.

本文言語English
ページ(範囲)486-491
ページ数6
ジャーナルPharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists
6
6
DOI
出版ステータスPublished - 1989 6

ASJC Scopus subject areas

  • バイオテクノロジー
  • 分子医療
  • 薬理学
  • 薬科学
  • 有機化学
  • 薬理学(医学)

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