Predictive and modifying factors of bone mineral density decline in patients with COPD

Naofumi Kameyama, Shotaro Chubachi, Mamoru Sasaki, Akihiro Tsutsumi, Hidehiro Irie, Kaori Sakurai, Koichi Sayama, Hidetoshi Nakamura, Koichiro Asano, Tomoko Betsuyaku, Koichi Fukunaga

研究成果: Article査読

2 被引用数 (Scopus)

抄録

Rationale: Various determinants of osteoporosis have been previously identified. However, only a few longitudinal studies have examined related factors. We aimed to investigate factors predicting and modifying rapid decline of bone mineral density in patients with chronic obstructive pulmonary disease. Methods: We analyzed patients with chronic obstructive pulmonary disease whose bone mineral density were measured at least three times over three years (n = 111). We divided annual per cent changes of bone mineral density in different body parts into tertiles. Rapid decliners (n = 33) were defined as those with the largest decline in at least two parts; all other participants were defined as non-rapid decliners (n = 78). Results: At enrollment, bone mineral density did not differ between the two groups. However, rapid decliners had a significantly greater rate of new vertebral fractures over 3 years compared with non-rapid decliners. On multivariate logistic regression analysis, age, moderate to severe emphysema, no daily exercise habits, and anemia increased the likelihood of rapid decliners. Furthermore, patients who newly started and continued bisphosphonate exhibited higher annual per cent changes of bone mineral density than did those without bisphosphonate use. Conclusions: A rapid decline in bone mineral density correlates to a higher likelihood of vertebral fracture. We clarified the predictors of bone mineral density decline and demonstrated that bisphosphonate use might modify bone mineral density in patients with chronic obstructive pulmonary disease.

本文言語English
ページ(範囲)13-23
ページ数11
ジャーナルRespiratory Medicine
148
DOI
出版ステータスPublished - 2019 3

ASJC Scopus subject areas

  • 呼吸器内科

フィンガープリント

「Predictive and modifying factors of bone mineral density decline in patients with COPD」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル