Predictive model for survival after liver resection for noncolorectal liver metastases in the modern era: a Japanese multicenter analysis

Taiga Wakabayashi, Taizo Hibi, Godai Yoneda, Yasuhito Iwao, Yu Sawada, Hiroyuki Hoshino, Shuichiro Uemura, Daisuke Ban, Atsushi Kudo, Yusuke Takemura, Kohei Mishima, Masahiro Shinoda, Osamu Itano, Takehito Otsubo, Itaru Endo, Yuko Kitagawa, Minoru Tanabe, Hiroto Egawa, Masakazu Yamamoto

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Background: Survival benefit of liver resection for noncolorectal liver metastases (NCRLM) remains to be defined. Methods: This multicenter, retrospective cohort analysis included consecutive patients with NCRLM whose primary tumor and all metastases were treated with curative intent between 2000 and 2013. The primary endpoint was 5-year overall survival. Clinicopathological factors that affected prognoses were identified using multivariate Cox regression analyses and were included in a predictive model. Results: Data for 205 patients were analyzed. The three most common primary tumor sites were stomach (39%), pancreas (13%), and urinary tract (10%), with adenocarcinomas the main pathology (52%). R0 resection was achieved in 85%, and the overall survival at 5 years was 41%. In the multivariate analysis, synchronous liver metastases, R1/2 resection, and adenocarcinomas and other carcinomas (with gastrointestinal stromal tumors, neuroendocrine tumors G1/G2, and sarcomas set as the reference group) were independent negative indicators of overall survival. A predictive model effectively stratified the NCRLM patients into low-, intermediate-, and high-risk groups with overall 5-year survival rates of 63%, 38%, and 21%, respectively (P < 0.001). Conclusions: Patients who underwent curative resection for metachronous disease and favorable tumor pathology are expected to have better survival in the NCRLM cohort.

元の言語English
ページ(範囲)441-448
ページ数8
ジャーナルJournal of Hepato-Biliary-Pancreatic Sciences
26
発行部数10
DOI
出版物ステータスPublished - 2019 10 1

ASJC Scopus subject areas

  • Medicine(all)

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    Wakabayashi, T., Hibi, T., Yoneda, G., Iwao, Y., Sawada, Y., Hoshino, H., Uemura, S., Ban, D., Kudo, A., Takemura, Y., Mishima, K., Shinoda, M., Itano, O., Otsubo, T., Endo, I., Kitagawa, Y., Tanabe, M., Egawa, H., & Yamamoto, M. (2019). Predictive model for survival after liver resection for noncolorectal liver metastases in the modern era: a Japanese multicenter analysis. Journal of Hepato-Biliary-Pancreatic Sciences, 26(10), 441-448. https://doi.org/10.1002/jhbp.654