Preferential Alternative Splicing in Cancer Generates a K-sam Messenger RNA with Higher Transforming Activity

Hiroshi Itoh, Yutaka Hattori, Hiromi Sakamoto, Hideshi Ishii, Tatsuya Kishi, Hiroki Sasaki, Teruhiko Yoshida, Masashi Koono, Takashi Sugimura, Masaaki Terada

研究成果: Article査読

70 被引用数 (Scopus)

抄録

K-sam, also designated fibroblast growth factor receptor 2/BEK, was originally cloned from a stomach cancer cell line KATO-III. The gene is amplified and overexpressed preferentially in poorly differentiated types of stomach cancers. The major K-sam transcript in KATO-III cells encodes a receptor protein with a truncated carboxyl terminus and with a high-affinity binding site for keratinocyte growth factor. This truncated type is produced by an alternative splicing mechanism, and in normal tissues, the truncated type is far less prevalent than the untruncated form. The variant K-sam complementary DNA lacks tyrosine 769, which is a putative phospholipase Cγ1 association site, and showed a higher transforming activity to NIH3T3 cells than the untruncated form, which is identical with the keratinocyte growth factor receptor.

本文言語English
ページ(範囲)3237-3241
ページ数5
ジャーナルCancer Research
54
12
出版ステータスPublished - 1994 6月 15
外部発表はい

ASJC Scopus subject areas

  • 腫瘍学
  • 癌研究

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