Preferential localization of CD8+ α(E)β7+ T cells around acinar epithelial cells with apoptosis in patients with Sjogren's syndrome

Tsutomu Fujihara, Hiromi Fujita, Kazuo Tsubota, Keiko Saito, Kensei Tsuzaka, Tohru Abe, Tsutomu Takeuchi

研究成果: Article査読

93 被引用数 (Scopus)

抄録

The T lymphocytes that infiltrate the exocrine glands in Sjogren's syndrome (SS) play a key role in damaging glandular epithelial cells, but the mechanisms of tiffs damage by T lymphocytes are not fully understood. To determine the cellular basis of this phenomenon, we focused our attention on the T lymphocytes around acinar epithelial cells in SS. We showed that CD8+ but not CD4+ T lymphocytes were located around the acinar epithelial cells and that a majority of these CD8+ T lymphocytes possess an unique integrin, α(E)β7 (CD103). The acinar epithelial cell adherent with α(E)β7 (CD103)+ CD8+ T lymphocytes was apoptotic. Both the perforin/granzyme B and Fas/Fas ligand pathways were implicated in the process of programmed cell death in lacrimal glands. These results suggested that α(E)β7 integrin, by interacting with E-cadherin, mediates the adhesion between CD8+ T lymphocytes and acinar epithelial cells in SS and participates in inducing epithelial cell apoptosis, leading to secretory dysfunction of exocrine glands, a hallmark of SS.

本文言語English
ページ(範囲)2226-2235
ページ数10
ジャーナルJournal of Immunology
163
4
出版ステータスPublished - 1999 8 15
外部発表はい

ASJC Scopus subject areas

  • 免疫アレルギー学
  • 免疫学

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「Preferential localization of CD8<sup>+</sup> α(E)β<sub>7</sub><sup>+</sup> T cells around acinar epithelial cells with apoptosis in patients with Sjogren's syndrome」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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