Premature ovarian failure in androgen receptor-deficient mice

Hiroko Shiina, Takahiro Matsumoto, Takashi Sato, Katsuhide Igarashi, Junko Miyamoto, Sayuri Takemasa, Matomo Sakari, Ichiro Takada, Takashi Nakamura, Daniel Metzger, Pierre Chambon, Jun Kanno, Hiroyuki Yoshikawa, Shigeaki Kato

研究成果: Article

210 引用 (Scopus)

抄録

Premature ovarian failure (POF) syndrome, an early decline of ovarian function in women, is frequently associated with X chromosome abnormalities ranging from various Xq deletions to complete loss of one of the X chromosomes. However, the genetic locus responsible for the POF remains unknown, and no candidate gene has been identified. Using the Cre/LoxP system, we have disrupted the mouse X chromosome androgen receptor (Ar) gene. Female AR-/- mice appeared normal but developed the POF phenotype with aberrant ovarian gene expression. Eight-week-old female AR-/- mice are fertile, but they have lower follicle numbers and impaired mammary development, and they produce only half of the normal number of pups per litter. Forty-week-old AR -/- mice are infertile because of complete loss of follicles. Genome-wide microarray analysis of mRNA from AR-/- ovaries revealed that a number of major regulators of folliculogenesis were under transcriptional control by AR. Our findings suggest that AR function is required for normal female reproduction, particularly folliculogenesis, and that AR is a potential therapeutic target in POF syndrome.

元の言語English
ページ(範囲)224-229
ページ数6
ジャーナルProceedings of the National Academy of Sciences of the United States of America
103
発行部数1
DOI
出版物ステータスPublished - 2006 1 3
外部発表Yes

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Primary Ovarian Insufficiency
X Chromosome
Genetic Loci
Androgen Receptors
Microarray Analysis
Chromosome Aberrations
Genes
Reproduction
Ovary
Breast
Genome
Phenotype
Gene Expression
Messenger RNA
mouse AR protein

ASJC Scopus subject areas

  • Genetics
  • General

これを引用

Shiina, H., Matsumoto, T., Sato, T., Igarashi, K., Miyamoto, J., Takemasa, S., ... Kato, S. (2006). Premature ovarian failure in androgen receptor-deficient mice. Proceedings of the National Academy of Sciences of the United States of America, 103(1), 224-229. https://doi.org/10.1073/pnas.0506736102

Premature ovarian failure in androgen receptor-deficient mice. / Shiina, Hiroko; Matsumoto, Takahiro; Sato, Takashi; Igarashi, Katsuhide; Miyamoto, Junko; Takemasa, Sayuri; Sakari, Matomo; Takada, Ichiro; Nakamura, Takashi; Metzger, Daniel; Chambon, Pierre; Kanno, Jun; Yoshikawa, Hiroyuki; Kato, Shigeaki.

:: Proceedings of the National Academy of Sciences of the United States of America, 巻 103, 番号 1, 03.01.2006, p. 224-229.

研究成果: Article

Shiina, H, Matsumoto, T, Sato, T, Igarashi, K, Miyamoto, J, Takemasa, S, Sakari, M, Takada, I, Nakamura, T, Metzger, D, Chambon, P, Kanno, J, Yoshikawa, H & Kato, S 2006, 'Premature ovarian failure in androgen receptor-deficient mice', Proceedings of the National Academy of Sciences of the United States of America, 巻. 103, 番号 1, pp. 224-229. https://doi.org/10.1073/pnas.0506736102
Shiina, Hiroko ; Matsumoto, Takahiro ; Sato, Takashi ; Igarashi, Katsuhide ; Miyamoto, Junko ; Takemasa, Sayuri ; Sakari, Matomo ; Takada, Ichiro ; Nakamura, Takashi ; Metzger, Daniel ; Chambon, Pierre ; Kanno, Jun ; Yoshikawa, Hiroyuki ; Kato, Shigeaki. / Premature ovarian failure in androgen receptor-deficient mice. :: Proceedings of the National Academy of Sciences of the United States of America. 2006 ; 巻 103, 番号 1. pp. 224-229.
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