Preparation and properties of phenytoin silica complex nanoparticles

H. Goto, T. Isobe, M. Senna

研究成果: Conference article査読

1 被引用数 (Scopus)

抄録

A sparingly soluble model drug, phenytoin (5,5-diphenyl-hydantoin, denoted as PT), was added during hydrolysis and polycondensation of tetra orthoethyl silicate (TEOS). The average size of the composite primary particles after in situ recrystallization of PT and gelation of silica was 2-3 nm. The extent of hydrogen bond (HB) in PT was reduced after the complex formation (CF), while many PT molecules were attached by HB on the surface of silica gel. The apparent solubility to ethanol decreased to 29% to approximately 18% by CF. The first-order rate constant of dissolution of PT into H2O increased by CF up to 40 times. Addition of acrylamide also enhanced the dissolution rate. Mechanisms of faster dissolution were discussed in terms of the hydrogen bond reformation and microstructure.

本文言語English
ページ(範囲)321-326
ページ数6
ジャーナルMaterials Research Society Symposium - Proceedings
501
出版ステータスPublished - 1998 1 1
イベントProceedings of the 1997 MRS Fall Symposium - Boston, MA, USA
継続期間: 1997 11 301997 12 3

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

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