抄録
Hollow nanoparticles (bionanocapsules) were prepared using liposomes as a template for the layerby-layer deposition of biopolymers. We carried out the alternative deposition of poly-L-lysine (PLys) and poly-L-aspartic acid (PAsP) onto a negatively charged liposome, which was prepared from dilauroyl phosphatidic acid (DLPA) and dimyristoylphosphatidylcholine (DMPC). Efficient separation of nanocapsules from unbound polymers was achieved by ultrafiltration. ζ-Potentials of nanocapsules changed between positive and negative charges at each deposition. FE-TEM revealed that the liposome was covered with a thin polymeric layer. A fluorescent probe, l-hydroxypyrene-3,6,8- trisulfonic acid (HPTS), was encapsulated into nanocapsules. The release of HPTS was suppressed by the polymer deposition, and the release rate was tunable by coverage of the first PLys layer and the ratio of DLPA.
本文言語 | English |
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ページ(範囲) | 5122-5128 |
ページ数 | 7 |
ジャーナル | Macromolecules |
巻 | 40 |
号 | 14 |
DOI | |
出版ステータス | Published - 2007 7月 10 |
ASJC Scopus subject areas
- 有機化学
- ポリマーおよびプラスチック
- 無機化学
- 材料化学