Preparation of Optically Active α-Hydroxy Acid Derivatives by Microbial Hydrolysis of Cyanohydrins and Its Application to the Synthesis of (R)-4-Dodecanolide

Hideaki Kakeya, Naoko Sakai, Takeshi Sugai, Hiromichi Ohta

研究成果: Article査読

1 被引用数 (Scopus)

抄録

Both enantiomers of aliphatic and aromatic cyanohydrins were hydrolyzed with the aid of Rhodococcus butanica ATCC 21197 to afford optically active α-hydroxy acids. The usefulness of this reaction is demonstrated by the synthesis of optically pure (R)-4-dodecanolide, a defensive secretion of rove beetles, starting from (R)-2-hydroxydecanenitrile.

本文言語English
ページ(範囲)1877-1881
ページ数5
ジャーナルAgricultural and biological chemistry
55
7
DOI
出版ステータスPublished - 1991

ASJC Scopus subject areas

  • 生化学、遺伝学、分子生物学(全般)
  • 農業および生物科学(全般)

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「Preparation of Optically Active α-Hydroxy Acid Derivatives by Microbial Hydrolysis of Cyanohydrins and Its Application to the Synthesis of (R)-4-Dodecanolide<sup>†</sup>」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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