Preparation Of Peptide-Carrying Microspheres With Bioactivity On Platelets

Yuji Kasuya, Keiji Fujimoto, Haruma Kawaguchi, Masaki Miyamoto, Takeo Juji, Akira Otaka, Susumu Funakoshi, Nobutaka Fujii

研究成果: Article査読

11 被引用数 (Scopus)

抄録

A tetrapeptide RGDS (Arg-Gly-Asp-Ser), which is one of the active sites of cell adhesive proteins, was synthesized according to the solution method and covalently coupled onto monodisperse microspheres. The biospecific activity of the RGDS-carrying microspheres was investigated by measuring the stimulatory effect of the microspheres on platelets. Large and tightly packed platelet aggregation accompanied with drastic ATP release was induced by the RGDS-carrying microspheres. It was confirmed that the specific platelet aggregation was attributed to the activity of the immobilized RGDS by comparison with those induced by other microspheres.

本文言語English
ページ(範囲)369-380
ページ数12
ジャーナルJournal of Biomaterials Science, Polymer Edition
4
4
DOI
出版ステータスPublished - 1993

ASJC Scopus subject areas

  • 生物理学
  • バイオエンジニアリング
  • 生体材料
  • 生体医工学

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