Preservation of hematopoietic properties in transplanted bone marrow cells in the brain

Kenji Ono, Ken Yoshihara, Hiromi Suzuki, Kenji F. Tanaka, Takemasa Takii, Kikuo Onozaki, Makoto Sawada

研究成果: Article

34 引用 (Scopus)

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Recent studies have described the possible transdifferentiation of bone marrow cells (BMC) into neurons and glia when they migrate to the brain. However, we have reported that some immature BMC migrating into the brain parenchyma after bone marrow transplantation express early hematopoietic markers but not neural or glial markers. The present study further characterizes transplanted BMC that migrate to the brain. Double immunolabeling confirmed that BMC migrating to the brain expressed hematopoietic but not neural markers, such as nestin, microtubule-associated protein-2 and glial fibrillary acidic protein, even 4 and 18 weeks after bone marrow transplantation. BMC that expressed green fluorescent protein also expressed hematopoietic but not neural markers when cultured with mixed brain cells according to double immunolabeling and single-cell dissection using a laser. Analysis of the DNA content indicated that most of the migrated BMC were arrested at the G0/G1 phase, and aneuploidy or tetraploidy was undetectable. Thus, BMC that migrate to the brain probably have preserved hematopoietic properties under physiological conditions.

元の言語English
ページ(範囲)503-507
ページ数5
ジャーナルJournal of neuroscience research
72
発行部数4
DOI
出版物ステータスPublished - 2003 5 15
外部発表Yes

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

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