Preserved effects of potassium channel blockers in the pacing-induced remodeled canine atrium: A comparison between E4031 and azimilide

Akiko Shiroshita-Takeshita, Hideo Mitamura, Toshiaki Sato, Kaori Shinagawa, Yasuo Kurita, Hideaki Kanki, Seiji Takatsuki, Motoki Hara, Satoshi Ogawa

研究成果: Article査読

3 被引用数 (Scopus)

抄録

This study was designed to evaluate the electrophysiologic effects of E4031 (a pure IKr blocker) and azimilide (AZ: a combined 1kr + IKs blocker) at various stages of atrial electrical remodeling. Twelve dogs underwent continuous rapid atrial pacing (400/min) for 14 days. The electrophysiologic study was performed on the day before as well as after 2, 7, and 14 days of rapid atrial pacing both before and after the administration of either E4031 (n = 6) or AZ (n = 6). In response to rapid atrial pacing, the atrial effective refractory period (ERP), conduction velocity, and wavelength decreased significantly at pacing cycle lengths (PCLs) of 200 and 400 ms (P < 0.05). E4031 prolonged ERP in a reverse use-dependent manner throughout the study period. AZ also prolonged ERP during the 14 days of rapid pacing. ERP prolongation at a PCL of 200 ms was significantly greater with AZ than with E4031 (P < 0.05). The effects of blocking IKr by E4031 and IKr + IKs by AZ were well preserved at various stages of atrial electrical remodeling. However, the effect of prolonging ERP at a shorter PCL was more prominent by AZ than by E4031. Thus, IKs blockade may add a favorable anti-fibrillatory effect to IKr blockade even in the remodeled atrium.

本文言語English
ページ(範囲)678-685
ページ数8
ジャーナルJournal of Cardiovascular Pharmacology
41
5
DOI
出版ステータスPublished - 2003 5 1

ASJC Scopus subject areas

  • 薬理学
  • 循環器および心血管医学

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