Presynaptic M1 muscarinic receptor modulates spontaneous release of acetylcholine from rat basal forebrain slices

Takeshi Suzuki, Kazuko Fujimoto, Hisayo Oohata, Koichiro Kawashima

研究成果: Article査読

51 被引用数 (Scopus)

抄録

Spontaneous release of acetylcholine (ACh) from rat basal forebrain slices in the presence of cholinesterase inhibitor was directly determined using a specific radioimmunoassay for ACh. The release was calcium dependent. A consistent amount of ACh release was observed throughout the experiment. Atropine (10-8 to 10-5 M) and pirenzepine (10-7 to 10-5 M) enhanced spontaneous ACh release. These findings indicate the presence of an M1 muscarinic autoreceptor that modulates spontaneous release of ACh in the rat basal forebrain.

本文言語English
ページ(範囲)209-212
ページ数4
ジャーナルNeuroscience Letters
84
2
DOI
出版ステータスPublished - 1988 1 22

ASJC Scopus subject areas

  • 神経科学(全般)

フィンガープリント

「Presynaptic M<sub>1</sub> muscarinic receptor modulates spontaneous release of acetylcholine from rat basal forebrain slices」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル