Prevention of intimal hyperplasia using short period vascular heating without surrounding tissue injury: In vitro/in vivo experiments and thermal conduction calculation

Eriko Suga, Kenji Kaneko, Hikaru Futami, Erika Yamashita, Tsunenori Arai

研究成果: Conference article査読

6 被引用数 (Scopus)

抄録

We have been proposed novel short-term (<10s) heating balloon using the combination of light-heat conversion mechanism and heated contrast medium irrigation in the balloon to improve dilatation characteristics of balloon angioplasty. Our new balloon angioplasty had suppressed intimal hyperplasia in rabbit model. We designed following experiments to understand the mechanism of suppression of intimal hyperplasia in our new thermal balloon angioplasty. We also aimed to obtain the suitable heating condition in our angioplasty to suppress intimal hyperplasia. We studied influence of the short-term heating on smooth muscle cells (SMCs) lethality in vitro. We investigated number of SMCs reduction in media in order to prevent intimal hyperplasia. We applied to our heating balloon dilatation to chronic rabbit model using normal iliac artery to study relation between heating condition and hyperplasia suppression. We estimated temperature history of the rabbit vascular wall by thermal conduction calculation. We related the estimated temperature history to the hyperplasia suppression effect in the chronic rabbit model. Finally, we obtained the relation between number of SMCs decreases and intimal hyperplasia suppression. We obtained that the short-term heating with 10s laser irradiation corresponding to estimated temperature of 50°C in the media and prevented intimal hyperplasia in the rabbit chronic model. In this case, we estimated about 30 percents of SMCs cellular lethality in media.

本文言語English
論文番号94
ページ(範囲)438-446
ページ数9
ジャーナルProgress in Biomedical Optics and Imaging - Proceedings of SPIE
5686
DOI
出版ステータスPublished - 2005 8 16
イベントPhotonic Therapeutics and Diagnostics - San Jose, CA, United States
継続期間: 2005 1 222005 1 25

ASJC Scopus subject areas

  • 電子材料、光学材料、および磁性材料
  • 生体材料
  • 原子分子物理学および光学
  • 放射線学、核医学およびイメージング

フィンガープリント

「Prevention of intimal hyperplasia using short period vascular heating without surrounding tissue injury: In vitro/in vivo experiments and thermal conduction calculation」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル